leukotriene receptor การใช้

• Another leukotriene receptor antagonist is montelukast ( Singulair ), taken once daily.
• Another leukotriene receptor antagonist is zafirlukast ( Accolate ).
• Some doctors have succeeded with a class of asthma drug called leukotriene receptor antagonists.
• Safety of leukotriene receptor antagonists in pregnancy.
• Accolate is one of a new class of drugs called leukotriene receptor antagonists aimed at treating asthma in tablet form.
• These two compounds are leukotriene receptor antagonists which block the action of specific leukotrienes, while zileuton inhibits leukotriene formation.
• Step 2 consists of increasing the dose of the current antihistamine, adding other antihistamines, or adding a leukotriene receptor antagonist such as montelukast.
• Montelukast, Zafirlukast, and Pranlukast are receptor antagonists for the Cysteinyl leukotriene receptor 1 which contributes to mediating the actions of LTC4, LTD4, and LTE4.
• The GPR17 receptor, also termed the uracil nucleotide / cysteinyl leukotriene receptor, was initially defined as a receptor for LTC4, LTD4, and uracil nucleotides.
• However, the first discovered receptor for these CsLTs, cysteinyl leukotriene receptor 1 ( CysLTR1 ), appears to play the major role in mediating these reactions.
• Because of their convenience ( and perceived safety ), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma.
• The first has long been identified with the Mayo Clinic, and it recommends treatment with beta agonists such as terbutaline, phosphodiesterase inhibitor theophylline and leukotriene receptor antagonists montelukast sodium.
• "' Cysteinyl leukotriene receptor 2 "', also termed CYSLTR2, is a receptor for cysteinyl leukotrienes ( LT ) ( see leukotrienes # Cysteinyl leukotrienes ).
• Various steroid sparing agents e . g . sodium cromoglycate ( a stabilizer of mast cell leukotriene receptor antagonist ) have been proposed, centering on an allergic hypothesis, with mixed results.
• "' Zafirlukast "'is an oral leukotriene receptor antagonist ( LTRA ) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and / or long-acting bronchodilator.
• Other studies on model cells for allergy have defined GPR17 ( also termed the uracil nucleotide / cysteinyl leukotriene receptor ) as a receptor not only uracil nucleotides but also for CysLTs, with CysLTs having the following potencies LTD4 > LTC4 > LTE4 in stimulating GPR17-bearing cells.
• LXA 4 and 15-epi-LXA 4 4 are also high affinity antagonists of the Cysteinyl leukotriene receptor 1 for which leukotrienes ( LT ) LTC4, LTD4, and LTE4 are agonists, i . e . the three leukotrienes bind to and thereby stimulate smooth muscle contraction, eosinophil chemotactaxis, mucous gland secretion, and various other pro-allergic responses in the cells of lung, skin, and other tissues . ( CysLT1 and ATX / FPR2 have an amino acid sequence identity of 47 % . ) The ability of these LX's to block the actions of the three LTs may contribute to their ability to resolve allergic reactions; for example, LXA4 relaxes the smooth muscle contraction caused by the cysteinyl leukotrienes in the hamster cheek pouch assay and a metabolically resistant 15-epi-LXAA 4 analog potently inhibits allergen-driven airway hypersensitivity and inflammation in a mouse model.